Inibidores da Metaloproteinase
publicado em 01/06/2001
Alain Thibodeau
Atrium Biotechnologies Inc., Quebec, Canadá
Os inibidores da metaloproteinase podem reduzir a atividade enzimática excessiva que degrada as fibras de colágeno, colapsa a trama da matriz extracelular da pele e produz sinais visíveis de envelhecimento.
Matrix metalloproteinase inhibitors can reduce the excess enzymatic activity that degrades collagen fibers, colapses the meshwork in the skin’s extracellular matrix, and leads to visible signs of aging.
Los inibidores de mataloproteinasa pueden reducir el exceso de actividad enzimática que degrada las fibras de colágeno, colapsa el entramado de la matriz extracelular de la piel y produce signos visibles de envejecimiento.
MEC e Envelhecimento da Pele
Controlando as MPMs
Ação das MPMs e dos ITMPs sobre o Colágeno
Ação Excessiva da MPM na MEC
Algumas Aplicações Cosméticas do Inibidores de MPM
Conclusão
As metaloproteinases da matriz são enzimas presentes na pele, responsáveis pela degradação das macromoléculas formadoras da matriz extracelular (MEC) da pele. A matriz extracelular desempenha papel importantíssimo nas diferentes funções biológicas, pois é ela que estabelece a integridade tridimensional da pele.
O equilíbrio enzimático das metaloproteinases é naturalmente controlado pela presença de inibidores. O envelhecimento e as agressões do meio-ambiente, como radiação UV, perturbam esse equilíbrio, favorecendo a atividade enzimática excessiva. Esse excesso de atividade resulta num colapso da trama da rede da matriz extracelular e contribui para os efeitos visíveis da lesão por UV; enrugamento, perda de elasticidade e dilatação dos vasos microcapilares de superfície.
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