Agentes de Clareamento de Pele
publicado em 18/04/2020
Howard I Maibach
University of California School of Medicine, San Francisco, CA, EUA
Michal WS Ong
King´s College, London, Reino Unido
Razões diversas levam o consumidor a procurar a despigmentação da pele. Os primeiros despigmentantes datam dos anos 1930. Neste artigo os autores descrevem recentes tratamento/ativos lançados nos últimos 5 anos.
Various reasons lead the consumer to seek depigmentation of the skin. The first depigmentants date back to the 1930s. In this article the authors describe recente treatment/assets released in the last 5 years.
Varias razones llevan al consumidor a buscar la despigmentación de la piel. Los primeros aclaradores datan de la década de 1930. En este artículo los autores describen recientes de tratamiento/activos disponibles a partir de los últimos cinco años.
Tetrapeptídeo PKEK
N-Acetil Glucosamina
Orquídea vs. 3% Vitamina C
Família do Artocarpus
Extrato de Morus alba
Conclusão
Distúrbios de pigmentação da pele são comuns e, embora muitas vezes não afetem fisicamente o consumidor, muitos o podem afetá-lo psicologicamente.1 Desde que foi descoberto o efeito de despigmentação do éter monobenzílico da hidroquinona, no final da década de 1930, grande número de compostos fenólicos vem sendo avaliado na inibição da síntese da melanina.2 Os agentes clareadores químicos mais comumente usados são hidroquinona, arbutina, ácido kójico e ácido ascórbico, mas, embora a maioria dos agentes clareadores da pele seja considerada efetiva, a hidroquinona ainda é vista pelos dermatologistas como um dos agentes mais efetivos. Contudo ocorrem efeitos colaterais, como queimaduras, coceira, formação de crostas, inchaço, descoloração da pele e ocronose — persistente pigmentação azul-marinho —, causados por alguns agentes de despigmentação, o que faz com que a busca por soluções novas e mais efetivas continue e seja cada vez mais instigante. Recentemente, passaram a ser descobertos novos agentes, especialmente de origem vegetal, cujo efeito de despigmentação tem sido testado in vitro e in vivo. Este artigo examina os agentes clareadores da pele, de algum interesse,
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1. PE Grimes. Disorders of pigmentation: Global issues of major cosmetic concern, West J Med 169(4):226–7, 1998
2. PGP Engasser, HI Maibach. Cosmetic and dermatology: Bleaching creams, J Am Acad Dermatol 15(2):143–7, 1981
3. AO Barel, M Paye, HI Maibach. Handbook of Cosmetic Science and Technology, 3rd edic, Informa Healthcare, 2009
4. A Marini et al. Modulation of skin pigmentation by the tetrapeptide PKEK: In vitro and in vivo evidence for skin whitening effects, Exp Dermatol 21(2):140–6, 2012
5. G Weindl, M Schaller, M Schäfer-Korting, HC Korting. Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects, Skin Pharmacol Physiol 17(5):207–13, 2004
6. T Sayo, S Sakai, S Inoue. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes, Skin Pharmacol Physiol 17(2):77–83, 2004
7. I Ghersetich, T Lotti, G Campanile, C Grappone, G Dini. Hyaluronic acid in cutaneous intrinsic aging, Int J Dermatol 33(2):119–22, 1994
8. DL Bissett, S McPhail. Topical N-acetyl glucosamine affects pigmentation-relevant genes in in vitro genomics testing, 19th edic, Pigment Cell Research, 2006
9. G Imokawa, Y Mishima. Importance of glycoproteins in the initiation of melanogenesis: An electron microscopic study
of B-16 melanoma cells after release from inhibition of glycosylation, J Invest Dermatol 87(3):319–25, 1986
10. Y Mishima, G Imokawa. Selective aberration and pigment loss in melanosomes of malignant melanoma cells in vitro by glycosylation inhibitors: Premelanosomes as glycoprotein, J Invest Dermatol 81(2):106–14, 1983
11. G Imokawa, Y Mishima. Loss of melanogenic properties in tyrosinases induced by
glucosylation inhibitors within malignant melanoma cells, Cancer Res 42(5):1994– 2002, 1982
12. DL Bissett, LR Robinson. Topical sugar amine reduces the appearance of hyperpigmented spots on human dorsal forearm and facial skin, 19th edic, Pigment Cell Research, 2006
13. DL Bissett, LR Robinson. Topical N-acetyl glucosamine reduces the appearance of hyperpigmented spots on human facial skin, J Am Acad Dermatol, 2006
14. DL Bissett et al. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine, J Cosmet Dermatol 6(1):20–6, 2007
15. AB Kimball et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: Results of a randomized, double-blind, vehicle-controlled trial, Br J Dermatol 162(2):435–41, 2010
16. T Tadokoro et al. Whitening effi cacy of plant extracts including orchid extracts on Japanese female skin with melasma and lentigo senilis, J Dermatol 37(6):522–30, 2010
17. K Shimizu, R Kondo, K Sakai, SH Lee, H Sato. The inhibitory components from Artocarpus incisus on melanin biosynthesis, Planta Med 64(5):408–12, 1998
18. P Tengamnuay, K Pengrungruangwong, I Pheansri, K Likhitwitayawuid. Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: Evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities, Int J Cosmetic Sci28(4):269–76, 2006
19. B Sritularak, W De-Eknamkul, K Likhitwitayawuid. Tyrosinase inhibitors from Artocarpus lakoocha, Thai J Pharm Sci 22:149–55, 1998
20. K Wachiranuntasin. Evaluation of Stability, antioxidative and free radical scavenging activities of Artocarpus lakoocha heartwood extract, Chulalongkorn University, Bangkok, 2005
21. W Zhu, J Gao. The use of botanical extracts as topical skin-lightening agents for the improvement of skin pigmentation disorders, J Invest Derm Symp Proc13(1):20–4, 2008
22. S Badreshia-Bansal, ZD Draelos. Insight into skin lightening cosmeceuticals for women of color, J Drugs Derm, 2007
23. S Nattapong, L Omboon. A new source of whitening agent from a Thai mulberry plant and its betulinic acid quantitation, Nat Prod Res 15-22(9):727–34, 2008
24. N Pianwijanpong, N Pongpan, L Suntornsuk, O Luanratana. The triterpene constituents of the root bark of a hybrid
between Morus alba L. and M-rotundiloba koidz. and its antityrosinase activities, Nat Prod Commun 2(4):381–4, 2007
25. K-H Wang et al. Cosmetic applications of selected traditional chinese herbal medicines, J Ethnopharmacol 19-106(3):353–9, 2006
26. KT Lee, KS Lee, JH Jeong, BK Jo, MY Heo, HP Kim. Inhibitory effects of Ramulus mori extracts on melanogenesis, J Cosmet Sci 54(2):133–42, 2003
27. SH Lee et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanina biosynthesis, Biol Pharm Bull 25(8):1045–8, 2002
28. YM Kim, J Yun, C-K Lee, H Lee, KR Min, Y Kim. Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action, J Biol Chem 277(18):16340–4, 2002
29. G Alvin, N Catambay, A Vergara, MJ Jamora. A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: A randomized, single-blind, placebo-controlled trial, J Drugs Dermatol10(9):1025–31, 2011
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