Envelhecimento Cutâneo: Terapias Terciárias
publicado em 26/04/2020
T Andreani e AM Silva
Centro de Investigação e Tecnologia Agroambientais e Biológicas (Citab-Utad), Vila Real, Portugal
JM Santos e JF Fangueiro
Universidade Fernando Pessoa (FCS-UFP), Porto, Portugal
MCT Truiti
Universidade Estadual do Maringá, Paraná, Brasil
EB Souto
Universidade de Trás-os-Montes e Alto Douro, Vila Real, Portugal
O recurso de utilizar terapias terciárias no combate ao envelhecimento cutâneo tem crescido exponencialmente, sendo uma alternativa às tradicionais formulações dermocosméticas. Este artigo visa fornecer informações sobre diferentes técnicas utilizadas na medicina estética e em dermatologia, de forma a obter um aspecto melhor dos sinais de envelhecimento intrínseco.
The use of tertiary therapies against anti-aging skin has grown exponentially, as na alternative to traditional dermocosmetic formulations. This article provides information on the different techniques used in aesthetic medicine and in dermatology, in order to obtain an improved aspect of the signs of intrinsic aging.
El uso de terapias terciarias contra la piel anti-envejecimiento ha crecido exponencialmente, como una alternativa a las formulaciones tradicionales dermocosméticas. En este artículo se proporciona información acerca de las diferentes técnicas que se utilizan en la medicina estética y en dermatología, con el fin de obtener un aspecto mejorado de los signos del envejecimiento intrínseco.
Peelings Químicos
Técnicas de Resurfacing
Sistemas de Laser
Preenchimentos (Fillers)
Toxinas Botulínicas
Mesoterapia
Terapia Fotodinâmica
Conclusão
A pele é o maior órgão do corpo humano, apresentando como principais funções a regulação da perda de água intrínseca e a prevenção da entrada de substâncias estranhas, como os microrganismos. É constituída por três camadas: a mais superficial, o estrato córneo (10-20μm); a intermédia, a epiderme (≈100μm); e a mais profunda, a derme (1.000-5.000μm).1 A irrigação da pele apenas acontece na derme, onde se situam os vasos sanguíneos. Assim, os ingredientes ativos que necessitam alcançar a corrente sanguínea devem necessariamente penetrar até a derme.
O envelhecimento cutâneo surge por meio de dois processos primários: (i) o intrínseco, devido a fatores genéticos que levam a mudanças estruturais e funcionais em todas as camadas da pele; (ii) e o extrínseco, causado por fatores ambientais, sendo os danos consequentes da exposição à radiação ultravioleta (UV) a principal causa ambiental desse tipo de envelhecimento.2,3 A radiação UV envolve radiações UVA (315-400nm) e UVB (290-315nm). Essas duas radiações atingem primeiro a epiderme. As radiações mais energéticas são as UVB, que causam danos agudos, como queimaduras solares, e podem induzir alterações no ácido desoxirribonucleico (ADN). Apesar das radiações UVA serem menos energéticas, são
Para visualizar o restante do artigo faça seu login ou então se cadastre gratuitamente e acesse todo o conteúdo disponível.
1. A Williams. Transdermal and topical drug delivery, Williams, A. Ed., London: Pharmaceutical Press, 2003
2. B Paula. Aging skin: causes, treatments, and prevention. Nursing Clinics of North America 42(3):485-500, 2007
3. L Robert, J Labat-Robert. AM Robert. Physiology of skin aging. Pathologie Biologie 57(4):336-341, 2009
4. C Vioux-Chagnoleau, F Lejeune, J Sok, C Pierrard, C Marionnet, F Bernerd. Reconstructed human skin: from photodamage to sunscreen photoprotection and anti-aging molecules. Journal of Dermatological Science Supplement 2(1):S1-S12, 2006
5. EC Naylor, REB Watson, MJ Sherratt. Molecular aspects of skin ageing. Maturitas 69(3):249-256, 2011.
6. MVR Velasco, FR Okubo, ME Ribeiro, D Steiner, V Bedin. Rejuvenescimento da pele por peeling químico: enfoque no peeling de fenol. Anais Brasileiros de Dermatologia 79(1):91-99, 2001
7. JH Rabe, AJ Mamelak, PJ McElgunn, WL Morison, DN Sauder. Photoaging: mechanisms and repair. Journal of the American Academy of Dermatology 55(1):1-19, 2006
8. MRA Hussein, EE Ab-Deif, AA Abdel-Motaleb, H Zedan, AM Abdel- Meguid. Chemical peeling and microdermabrasion of the skin: comparative immunohistological and ultrastructural studies. Journal of Dermatological Science 52(3):205-209, 2008
9. N Cassano, G Alessandrini, M Mastrolonardo, GA Vena. Peeling agents: toxicological and allergological aspects. Journal of the European Academy of Dermatology and Venereology 13(1):14- 23, 1999
10. A Green, RJ Yu, EJ Van Scott. Clinical and cosmeceutical uses of hydroxyacids. Clinics in Dermatology 27(5):495 501, 2009
11. SN Andrews, V Zarnitsyn, B Bondy, MR Prausnitz. Optimization of microdermabrasion for controlled removal of stratum corneum. International Journal of Pharmaceutics 407(1–2):95-104, 2011
12. SJ Beran, RW Bernard. Microdermabrasion. Aesthetic Surgery Journal 20(3):38-239, 2000
13. EK Shim, D Barnette, K Hughes, HT Greenway. Microdermabrasion: a clinical and histopathologic study. Dermatologic Surgery 27(6):524-530 2001
14. HS Edward. Microepidermabrasion: an adjunct to medical skin care. Otolaryngologic Clinics of North America 35(1):135-151, 2002
15. DJ Karimipour, S Kang, TM Johnson, JS Orringer, T Hamilton, C Hammerberg, JJ Voorhees, G Fisher. Microdermabrasion: a molecular analysis following a single treatment. Journal of the American Academy of Dermatology 52(2):215-223, 2005
16. HS Gill, SN Andrews, SK Sakthivel, A Fedanov, IR Williams, DA Garber, FH Priddy, S Yellin, MB Feinberg, SI Staprans, MR Prausnitz. Selective removal of stratum corneum by microdermabrasion to increase skin permeability. European Journal of Pharmaceutical Sciences 38(2):95-103, 2009
17. ER Thomas. Lasers and cosmetic dermatologic surgery for aging skin. Clinics in Geriatric Medicine 17(4):769-794, 2001
18. NB Meduri. Facial resurfacing: an overview. Operative Techniques in Otolaryngology-Head and Neck Surgery 18(3):172-180, 2007
19. R Kaufmann, C Beier. Laser skin ablation: an update on aesthetic and medical indications. Medical Laser Application 19(4):212-222, 2004
20. MR Alexiades-Armenakas, JS Dover, KA Arndt. The spectrum of laser skin resurfacing: nonablative, fractional, and ablative laser resurfacing. Journal of the American Academy of Dermatology 58(5):719-737, 2008
21. MP Goldman, N Marchell, RE Fitzpatrick. Laser skin resurfacing of the face with a combined CO2/Er:YAG laser. Dermatologic Surgery 26(2):102-104, 2000
22. DJ Fife, RE Fitzpatrick, CB Zachary. Complications of fractional CO2 laser resurfacing: four cases. Lasers in Surgery and Medicine 41(3):179-184, 2009
23. DM DeHoratius, JS Dover. Nonablative tissue remodeling and photorejuvenation. Clinics in Dermatology 25(5):474-479, 2007
24. RA Weiss, DH McDaniel, RG Geronemus. Review of nonablative photorejuvenation: reversal of the aging effects of the sun and environmental damage using laser and light sources. Seminars in Cutaneous Medicine and Surgery 22(2):93-106, 2003
25. EP Tierney, CW Hanke. Recent advances in combination treatments for photoaging: review of the literature. Dermatologic Surgery 36(6):829-840, 2010
26. M El-Domyati, TS el-Ammawi, W Medhat, O Moawad, D Brennan, MG Mahoney, J Uitto. Radiofrequency facial rejuvenation: evidencebased effect. Journal of the American Academy of Dermatology 64(3):524-535, 2011
27. I Sánchez-Carpintero, D Candelas, R Ruiz-Rodríguez. Dermal fillers: types, indications, and complications. Actas Dermosifiliograficas 101(5):829-840, 2010
28. US Zimmermann, TJ Clerici. The histological aspects of fillers complications. Seminars in Cutaneous Medicine and Surgery 23(4):241-250, 2004
29. L Requena, C Requena, L Christensen, US Zimmermann, H Kutzner, L Cerroni. Adverse reactions to injectable soft tissue fillers. Journal of the American Academy of Dermatology 64(1):1-34, 2011
30. AW Kein. Complications and adverse reactions with the use of botulinum toxin. Seminars in Cutaneous Medicine and Surgery 20(2):109-12, 2001
31. PS Yamauchi. Selection and preference for botulinum toxins in the management of photoaging and facial lines: patient and physician considerations. Patient Prefer Adherence 4:345-354, 2010
32. TV Cartee, GD Monheit. An overview of botulinum toxins: past, present, and future. Clinics in Plastic Surgery 38(3):409-426, 2011
33. C Hexsel, D Hexsel, MD Porto, J Schilling, C Siega. Botulinum toxin type A for aging face and aesthetic uses. Dermatology and Therapy 24(1):54-61, 2011
34. M Iorizzo, MP De Padova, A Tosti. Biorejuvenation: theory and practice. Clinics in Dermatology 26(2):177-181, 2008 35. F Faresi, H Galadari. Mesotherapy: myth and reality. Expert Review of Dermatology 6(2):157-162, 2011
36. CA Morton, KE McKenna, LE Rhodes. Guidelines for topical photodynamic therapy: update. British Journal of Dermatology 159(6):1245-1266, 2008
37. ML Elsaie, Cutaneous remodeling and photorejuvenation using radiofrequency devices. Indian Journal of Dermatology 54(3):201- 205, 2009
38. G Buggiani, M Troiano, R Rossi, T Lotti. Photodynamic therapy: off-label and alternative use in dermatological practice. Photodiagnosis Photodynamic Therapy 5(2):134-138, 2008
Deixar comentário
Para comentar é preciso fazer login no sistema.