Antioxidantes de Origem Vegetal em Cosméticos
publicado em 07/05/2020
Júlia Scherer Santos
Farmacêutica, Curitiba PR, Brasil.
Este estudo teve por finalidade compilar as ações fotoprotetoras descritas para polifenóis de chá verde, flavonoides do cardo mariano, isoflavona da soja, proantocianidinas da semente de uva, extrato de marcela, extrato de alecrim, ginseng vermelho, flavonoides do cacau, samambaia, extrato do pinheiro-bravo, curcuma e prunella.
This study had aimed compile the photoprotective actions described for green tea polyphenols,milk thistle, soy isoflavones, proanthocyanidins from grape seed extract, marcela extract, rosemary extract, red ginseng, cacao flavonoids, fern plant, pine bark extract, Javanese turmeric, prunella.
Este estudio tiene como objetivo la conpilar las acciones protectoras descritas para el polifenoles del té verde, Marian caldo flavonoides, isoflavonas de soya, las proantocianidinas del extracto de semilla de uva, marcela extracto, extracto de romero, ginseng rojo, los flavonoides del cacao, helecho, extracto de pine, la cúrcuma y prunella.
Chá verde | Silimarina | Silibina | Picnogenol | Alecrim | Prunella | Flavonoides do cacau | Genisteína | Samambaia | Ginseng vermelho | Curcuma | Marcela | Semente da uva
A preocupação com os efeitos provocados pela radiação ultravioleta (UV), que sabidamente pode iniciar o desenvolvimento de câncer além de causar fotoenvelhecimento, implica necessidade do uso de agentes fotoprotetores. Esses agentes incluem os filtros solares físicos e químicos, e outros agentes que atuam protegendo a pele dos efeitos solares de modo diferenciado (Figura 1).
A exposição à radiação UV gera radicais livres, que iniciam no organismo uma cascata de reações. Inicialmente, os radicais livres ativam receptores de superfície, como interleucina-1 e fator de necrose, e o crescimento tumoral dos queratinócitos (TNF). A ativação dos receptores leva à ativação de proteína quinase por mitógeno (MAPK). Por sua vez, esta ativa o
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1. M Yaar, BA Gilchrest. Photoageing: mechanism, prevention and therapy, Brit. J Derm 157: 874-887, 2007
2. MA Farage, KW Miller, P Elsner, HI Maibach. Intrinsic and extrinsic factors in skin ageing: a Review, Int J Cosm Sci 30:87–95, 2008
3. P Baeuerle, D Baltimore. NF-kappa B: ten years after, Cell 87:13–20, 1996
4. Nabiha Yusuf, C Irby, KS Katiyar, C Elmets. Photoprotective effects of green tea polyphenols, Photodermatol. Photoimmunol Photomed 23:48–56, 2007
5. CD Mnich, SK Hoek, L Virkki, A Farkas, C Dudli, E Laine, Mirjana Urosevic, Reinhard Dummer. Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls, Exp Dermatol 18:69–77, 2009
6. G Jenkins. Molecular mechanisms of skin ageing. Mech Ageing Dev 123:801-810, 2002
7. AB Sharangi. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.)- A review, Food Research International 42:29-535, 2009
8. C Cabrera, R Artacho, R Gimenez. Benefi cial effects of green tea- a review. J Am Coll Nutr 25:79-99, 2006
9. PK Vayalil, A Mittal, Y Hara, CA Elmets, SK Katiyar PK Katiyar. Green Tea Polyphenols Prevent Ultraviolet Light Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin, J Invest Dermatol 122:1480 1487, 2004
10. MM Camouse, DS Domingo, FR Swain, E Conrad, M Matsui, D Maes, L Declercq, K Cooper, SR Stevens, E Baron. Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin, Exp Dermatol 18:522–526, 2009
11. YH Li, Y Wu, HC Wei, YY Xu, LL Jia, J Chen, XS Yang, GH Dong, XH Gao, HD Chen. Protective effects of green tea extracts on photoaging and photommunosuppression, Skin Res and Technol 15:338–345, 2009
12. F Afaq, VM Adhami, N Ahmad, H Mukhtar. Inhibition of ultraviolet Bmediated activation of nuclear factor B in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate, Oncogene 22, 1035–1044, 2003
13. SE Tobi, M Gilbert, N Paul, TJ McMillan. The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation, Int J Cancer 102:439–44, 2002
14. SK Katiyar, F Afaq, A Perez, H Mukhtar. Green tea polyphenol (_)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress, Carcinogenesis 22:287–294, 2001
15. SK Katiyar, A Challa, TS McCormick, KD Cooper, H Mukhtar. Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (_)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production, Carcinogenesis 20:2117–2124, 1999
16. M Barthelman, WB Bair, KK Stickland, W Chen, BN Timmermann, S Valcic, Z Dong, GT Bowden. (-)- Epigallocatechin-3-gallate inhibitiom of ultraviolet-B-induced AP-1 activity, Carcinogenesis 19:2201-2204, 1998
17. T Yamamoto, S Hsu, J Lewis, J Wataha, D Dickinson, B Singh, WB Bollag, P Lockwood, E Ueta, T Osaki, G Schuster. Green Tea Polyphenol Causes Differential Oxidative Environments in Tumor versus Normal Epithelial Cells, JPET 307:230–236, 2003
18. SK Katiyar, S Meleth, SD Sharma. Silymarin, a flavonoid from milk thistke (Silybum marianum L.), inhibits UV induced oxidative stress through targeting infiltrating CD11b+ cells in mouse skin, Photoch Photob 84:266-271, 2008
19. RP Singh, AK Tyagi, J Zhao, R Agarwal. et al. Silymarin inhibits growth and causes regression of estabilished skin tumorsin SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis, Carcinogenesis 23:499-410, 2002
20. S Dhanalakshmi, GU Mallikarjuna, RP Singh, R Agarwal. Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and up-regulation of p53-p21/Cip1 in epidermis, Carcinogenesis 25:459-1465, 2004
21. RP Singh, S Dhanalakshmi, S Mohan, C Agarwal, R Agarwal. Silibinin inhibits UVB- and epidermal growth factor– induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-KB in mouse epidermal JB6 cells, Mol Cancer Ther 5:1145- 1152, 2006
22. M Gu, RP Singh, S Dhanalakshmi, C Agarwal, R Agarwal. Silibinin Inhibits Inflammatory and Angiogenic Attributes in Photocarcinogenesis in SKH-1 Hairless Mice, Cancer Res 67:3483-3491, 2007
23. HS Cho, MH Lee, JW Lee, KO No, SK Park, HS Lee, S Kang, WG Cho, HJ Park, KW Oh, JT Hong, WG Cho. Anti wrinkling effects of the mixture of vitamin C, vitamin E, pycnogenol and evening primrose oil, and molecular mechanisms on hairless mouse skin caused by chronic ultraviolet B irradiation, Photodermatol Photoimmunol Photomed 23:155–162, 2007
24. R Martin, C Pierrard, F Lejeune, P Hilaire, L Breton, F Bernerd. Photoprotective effect of a water-soluble extract of Rosmarinus officinalis L. against UV-induced matrix metalloproteinase-1 in human dermal fibroblasts and reconstructed skin, Eur J Dermatol 18:128-35, 2008
25. G Sancheti, PK Goyal. Effect of Rosmarinus officinalis in Modulating 7,12-Dimethylbenz(a)anthracene induced Skin Tumorigenesis in Mice, Phytother Res 20,981–986, 2006
26. J Psotova, A Svobodova, H Kolarova, D Walterova. Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes, JPPB 84:167–174, 2006
27. U Heinrich, K Neukam, H Tronnier, H Sies, W Stahl. Long-Term Ingestion of High Flavanol Cocoa Provides Photoprotection against UV-Induced Erythema and Improves Skin Condition in Women, J Nutr 136:1565–1569, 2006
28. JO Moore, Y Wang, WG Stebbins, D Gao, X Zhou, R Phelps, M Lebwohl, H Wei. Photoprotective effect of isofl avone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression. in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis, Carcinogenesis 27:1627–1635, 2006
29. S Kang, JH Chung, JH Lee, GJ Fisher, YS Wan, EA Duell, JJ Voorhees. Topical N-Acetyl Cysteine and Genistein Prevent Ultraviolet- Light-Induced Signaling That Leads to Photoaging in Human Skin in vivo. J Invest Dermatol 120:835-841, 2003
30. MV Alcaraz, MA Pathak, F Rius, N Kollians, S Gonzales. An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model. Photodermatol Photoimmunol Photomed 15:120–126, 1999
31. A Maritza. Middelkamp-Hup et al. Orally administered Polypodium leucotomos extract decreases psoralen-UVA induced phototoxicity, pigmentation, and damage of human skin, J Am Acad Dermatol 50:41-49, 2004
32. N Philips, J Smitha, T Kellera, S Gonzalez. Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultravioleta radiation exposed fibroblasts, and Keratinocytes, J Dermatol Sci 32:1-9, 2003
33. MA Middelkamp-Hup, MA Pathak, C Parrado, D Goukassian, F Rius-Díaz, MC Mihm, TB Fitzpatrick, S González. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin, J Am Acad Dermatol 51:910-8, 2004
34. HJ Lee, JS Kim, MS Song, HS Seo, C Moon, JC Kim, SK Jo, JS Jang, SH Kim. Photoprotective Effect of Red Ginseng against Ultraviolet Radiation-induced Chronic Skin Damage in the Hairless Mouse, Phytother Res 23:399–403, 2009
35. T Kang, HM Park, YB Kim, H Kim, N Kim, JH Do, C Kang, Y Cho, SY Kim. Effects of red ginseng extract on UVB irradiationinduced skin aging in hairless mice, J Ethnopharmacol 123:446- 51, 2009
36. HI Oh, JS Shim, SH Gwon, HJ Kwon, JK Hwang. The Effect of Xanthorrhizol on the Expression of Matrix Metalloproteinase-1 and Type-I Procollagen in Ultraviolet-Irradiated Human Skin Fibroblasts. Phytother Res 23:1299–1302, 2009
37. A Morquio, F Rivera-Megret, F Dajas. Photoprotection by Topical Application of Achyrocline satureioides (‘Marcela’), Phytother Res 19:486–490, 2005
38. SK Katiyar. Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system, Mol Nutr Food Res 52:S71–S76, 2008
39. SK Mantena, SK Katiyar. Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-κB signaling in human epidermal keratinocytes, Free Radic Biol Med. 40:1603–1614, 2006
40. A Mittal, CA Elmets, SK Katiyar. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation, Carcinogenesis 24:1379-1388, 2003
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